Like all the stations along I-25, Southmoor Station is on the west side of the highway, just south of Hampden Avenue. A pedestrian tunnel under I-25 provides access to the platform and the park-n-Ride. RTD has incorporated art into the tunnel design, primarily using light. The Southmoor park-n-Ride has spaces for more than 860 vehicles.

Southmoor Station includes elements that provide passengers comfort, safety, wheelchair accessibility and protection from the weather. These elements include four benches per platform, glass-enclosed elevator towers, where appropriate, and gabled platform canopies. The canopy surface is an opaque, weather-resistant material that will diffuse daylight and filter station lights at night. Each station also has lockers for bicycles. Closed-circuit television cameras, located at key locations, provide enhanced security.